منابع مشابه
Regulation of microRNA biogenesis and function.
MicroRNAs (miRNAs) are considered as key regulators of literally all cellular pathways. Therefore, miRNA biosynthesis and their individual cellular functions must be tightly regulated as well. MiRNAs are transcribed as primary transcripts, which are processed to mature miRNAs in two consecutive maturation steps. Finally, the mature miRNA is incorporated into a miRNA-protein complex, where it di...
متن کاملMicroRNA regulation of vascular smooth muscle function and phenotype: early career committee contribution.
n periods of health, the vascular smooth muscle cell (VSMC) predominantly functions to regulate vascular tone and to provide structural integrity to the vascular tree. However, the VSMC is also one of the most plastic cells in the body. Under periods of stress, or in response to disease stimuli, the VSMC deviates from its physiologic state and can become hyperproliferative, migratory and/or pro...
متن کاملRegulation of Vascular Function on Posttranscriptional Level
Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence ca...
متن کاملRegulation of vascular endothelial barrier function.
The increase in endothelial permeability in response to inflammatory mediators such as alpha-thrombin and histamine is accompanied by cell rounding and interendothelial gap formation, implicating that the predominant transport pathway is a diffusive one [i.e., via cellular junctions (paracellular transport)]. However, the possible contribution by vesicle-mediated transport (i.e., via albumin bi...
متن کاملRegulation of vascular function by haemoglobin.
A critical element in the ability of endothelial NO to function in the vasculature is preventing its reaction with erythrocytic Hb (haemoglobin). Emerging concepts suggest that the biophysical and rheological properties of the red blood cell are important in meeting this criterion. It has been recognized for some time that cell-free Hb may react with endothelial NO and that this may underlie th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vascular Biology
سال: 2019
ISSN: 2516-5658
DOI: 10.1530/vb-19-0009